Kule minyaka eyishumi edlule, ucwaningo nokuthuthukiswa kwemithi yamehlo kuye kwaholela ezindleleni ezintsha zokulethwa ezijabulisayo, ezifana nezimila ezifika ngesikhathi kanye nama-nanoparticles angena ngamafinyila, angathuthukisa ukusebenza kwezidakamizwa, anciphise imiphumela engemihle, futhi anciphise ukukhathazeka ngokuhambisana nesiguli ngemithi yamehlo. .amaconsi.izindlela.
Ama-contact lens abhekwa njengendlela ethembisayo, futhi amalensi ambozwe ngezidakamizwa okwamanje asaphenywa izifo, isifo samehlo esomile (DES), i-glaucoma, kanye nokungezwani komzimba nezinto ezithile.eyodwa
Первая контактная линза с лекарственным покрытием, получившая одобрение FDA ранее в этом году (Acuvue Theravision с кетотифеном [Johnson & Johnson Vision]), представляет собой этафилкон А для ежедневного применения, обладающий противовоспалительными свойствами, обычно используемый в глазных каплях от аллергии. Ilensi yokuqala yokuxhumana ehlanganiswe nomuthi ukuthola imvume ye-FDA ekuqaleni kwalo nyaka (i-Acuvue Theravision with Ketotifen [Johnson & Johnson Vision]), iyi-etafilcon A yansuku zonke evimbela ukuvuvukala, evame ukusetshenziswa kumaconsi ehlweni e-allergies.i-ketotifen.
Amalensi Okuxhumana Aziwa Kakhulu
Ama-contact lens asebenza kahle njengamaconsi esweni.2 Njengoba lena kuyindlela entsha yokufaka, phakathi nocwaningo lomtholampilo lwale lensi yokuxhumana, mina nozakwethu siqoqe idatha eyengeziwe ukuze iphelele.
Sihlaziye izivivinyo ezingu-2 zomtholampilo ngedizayini efanayo elawulwa ngokungahleliwe ye-multicentre, ehlanganisa iziguli ezingaphezu kuka-500.Imiphumela, esanda kushicilelwa ku-Clinical and Experimental Optometry, ipenda isithombe esithembisayo ezigulini, odokotela, kanye nekusasa lale nqubo.3
Ukusetshenziswa isikhathi eside kwamaconsi esweni kuyaziwa ukuthi kuholela ekuhlanganiseni okubangelwa izidakamizwa - ubomvu, ukuvuvukala nokushiswa kwamehlo ngemva kokuchayeka isikhathi eside ezingxenyeni zamaconsi (ngokuyinhloko ama-preservatives).ezine
Lokhu kuphatheka kabi akuphazamisi nje kuphela imisebenzi yesiguli yansuku zonke kanye nezinga lempilo, kodwa futhi kuvimbela isiguli ukuthi siqhubeke sisebenzisa amaconsi emehlweni ngoba isiguli asifuni ukufaka amanye amathonsi esweni esweni eselivele licasukile.5
Uma isiguli sinalesi simo, ukubola kwe-corneal ngokuvamile kubonisa ukuphazamiseka kobuqotho be-corneal epithelium, okusikisela ukuthi ukwelashwa kufanele kulungiswe ukuze kusize iso liphulukise futhi kuvimbele ukulimala okwengeziwe.
Ukugwema ukuthintana namakhemikhali anokhahlo, njengamehlo alimale kabi, kubaluleke kakhulu ekwehliseni i-conjunctivitis ebangelwa izidakamizwa.
Umthamo ovamile uyadingeka ngoba amaconsi esweni ane-bioavailability ephansi—kuphela u-5–10% womuthi otholakala ebusweni beso6—futhi agezwa ngokushesha ngokucwayiza nokuqhunyiswa.
Amalensi okuxhumana ahlanganiswe ngomuthi ahlinzeka ngenani lezinzuzo ezingaqeda ezinye zezinkinga ezihlobene namaconsi amehlo, okuhlanganisa:
Umuthi wengezwe ku-lens phakathi nenqubo yokukhiqiza, ehlanganisa nesinyathelo sokuvala inzalo ye-autoclave.Ngakho-ke, azidingi izilondolozi ezifana ne-BAC, eziphula izibopho phakathi kwamaseli e-corneal epithelial.Ilensi ngayinye inikeza umthamo oyinyumba womuthi.
Amalensi okuxhumana ahlanganiswe nemithi aletha imithi phakathi namahora, ngakho ahlala phezu kweso isikhathi eside kunamaconsi esweni ageza ngokushesha.Iphrofayili yokukhishwa okususelwe ekusakazeni kwamalensi okuxhumana ibavumela ukuthi balethe imithamo engaguquki kunemithamo evamile edingekayo kwamanye amaconsi esweni.
Ngokuhlanganisa ukwelashwa kwezokwelapha nokulungiswa kombono kumalensi okuxhumana alahlwayo e-etafilcon A, iziguli azidingi ukucabanga ngesimiso somuthi.Lena inzuzo ethembisayo ikakhulukazi ezigulini ezikuthola kunzima ukuhlala ohlelweni.
Amalensi okuxhumana ahlanganiswe nemithi angakwazi ukuxazulula ezinye zezinkinga ezihlobene namaconsi esweni, kodwa umbuzo olandelayo onengqondo wochwepheshe bokunakekelwa kwamehlo uthi, “Iyini imiphumela yokugqoka nsuku zonke amalensi anemithi ebusweni beso?”
Amalensi Okuxhumana Aziwa Kakhulu
Mina nozakwethu sahlaziya idatha evela ezivivinyweni ezimbili ezifanayo zokuphepha zomtholampilo ezathatha amasonto ayi-12 futhi zahlanganisa ingqikithi yabafake amalensi oxhumana nabo abangu-560.Iziguli ezingama-374 zazigqoke amalensi okuhlola kanti iziguli eziyi-186 zazifake amalensi e-placebo.
Ukugcotshwa kwe-Cornea nge-fluorescein kwenziwa ekuqaleni kwase kuthi ngemva kwamaviki angu-1, 4, 8, nayi-12 okugqoka ilensi.Awukho umehluko obalulekile ngokwezibalo ekungcoleni phakathi kweqembu le-lens embozwe umuthi kanye neqembu le-placebo kukho konke ukuvakasha (95.86% kanye nama-95.88% ebangeni 0, ngokulandelana, emavikini ayi-12).Wonke amabala ayelula noma alandela umkhondo.
Ngemuva kwamaviki angu-4 okugqokwa, womabili amaqembu ahlangabezane nokuncipha okuvamile kokungcoliswa kwe-corneal kusukela kwesisekelo.Lokhu kushintsha okuphawulekayo kungase kubangelwe iziguli ezishintshayo zisuka kumalensi azo avamile ziye entweni entsha (etafilcon A, enamanzi amaningi7) kanye/noma uhlobo lokugqoka (kanye ngosuku, olukhipha isibalo ku-equation) ukuhlanza. ama-lens esixazululo).Ukunamathela kumalensi ocwaningo kwakufana kuwo womabili amaqembu (cishe ama-92%).
Ekuphetheni, esifundweni somtholampilo esikhulu, esilawulwa kahle, esiyimpumputhe kabili, singaphetha ngokuzethemba ukuthi le lens yokuxhumana ekhulula i-antihistamine ayithinti kakhulu ubuqotho be-corneal epithelium.
Amehlo agqoke lawa ma-contact lens ahlanganiswe nezidakamizwa akufanele abukeke ehlukile kunamehlo agqoke amalensi okuxhumana angaphili, okuyisici esibalulekile sokuhlanganiswa okungenamthungo ekusebenzeni kwalesi simiso.
Awukho umehluko enqubweni yokufaka ama-lens noma ukuhlola umbono.Iziguli zidinga nje ukwazi okwengeziwe ngamalensi ukuze zithole umbono eziwufunayo futhi zithole usizo olwengeziwe ngokungezwani neso.
Ubufakazi bokuthi ukungezwa kwama-antihistamine akukhulisi umonakalo we-corneal epithelial uma kuqhathaniswa namalensi okuxhumana ajwayelekile buyakhuthaza njengoba sibheke phambili ekusetshenzisweni okwengeziwe kwezindlela ezihlanganiswe nezidakamizwa.
Isikhathi sokuthumela: Aug-18-2022
