Sisebenzisa amakhukhi ukuthuthukisa ulwazi lwakho.Ngokuqhubeka upheqa lesi sizindalwazi uyavumelana nokusetshenziswa kwethu kwamakhukhi.Ulwazi olwengeziwe.
Ishicilela kujenali i-Additive Manufacturing, ithimba labacwaningi abavela ku-Manipal Institute of Higher Education e-India babika ngokwakhiwa kwelensi yokuxhumana yokumanzisa eyi-3D ephrintiwe. imishini yezokwelapha esekelwe ilensi yokuxhumana yesizukulwane esilandelayo.
Amalensi okuxhumana ahlakaniphile
Isifundo: Amalensi Wokuxhumana Wokuzimanzisa Asebenzisa I-Capillary Flow.Ikhredithi yesithombe: Kichigin/Shutterstock.com
Ama-contact lens avame ukusetshenziselwa ukulungisa ukubona futhi anenzuzo yokuba lula ukugqokwa kunezibuko.Ukwengeza, anemisebenzi yezimonyo, njengoba abanye abantu bewathola ejabulisa kakhulu.Ngaphezu kwalokhu kusetshenziswa kwendabuko, amalensi okuxhumana asehloliwe ukuze asetshenziswe. ku-biomedicine ukuthuthukisa amadivaysi enzwa ehlakaniphile angahlaseli kanye nokuxilongwa kwephuzu lokunakekelwa.
Kuye kwenziwa ucwaningo oluningana kule ndawo futhi sekusungulwe izinto ezintsha eziphawulekayo.Isibonelo, i-Google lens iyilensi yokuxhumana ehlakaniphile engasetshenziswa ukuqapha amazinga eglucose ngezinyembezi futhi inikeze ulwazi lokuxilonga kubantu abanesifo sikashukela.Ingcindezi ye-intraocular kanye neso ukunyakaza kungagadwa kusetshenziswa amadivaysi ahlakaniphile.Izinto eziqukethwe yi-Nanostructured zifakwe kuma-smart contact lens-based sensor platforms ukuze zisebenze njengezinzwa.
Nokho, ukusetshenziswa kwalezi zisetshenziswa kungaba inselele, kuvimbele ukuthuthukiswa kwezentengiselwano kwamapulatifomu asekelwe kumalensi.Ukugqoka amalensi okuxhumana isikhathi eside kungabangela ukungakhululeki, futhi avame ukoma, kubangele izinkinga eziningi kumuntu owagqokile. kuphazamisa inqubo yemvelo yokucwayiza, okuholela ekungagcinini kwamanzi okwanele kanye nokulimala kwezicubu ezithambile zeso lomuntu.
Izindlela zendabuko zihlanganisa amaconsi amehlo kanye nama-punctal plugs, athuthukisa ukugqugquzelwa kwezinyembezi ukuze akhiphe amanzi emehlweni.Izindlela ezimbili zamanoveli zenziwe eminyakeni yamuva nje.
Endleleni yokuqala, i-graphene yongqimba olulodwa isetshenziselwa ukunciphisa ukuhwamuka kwamanzi, nakuba le ndlela ivinjelwa izindlela zokukhiqiza eziyinkimbinkimbi.Endleleni yesibili, ukugeleza kwe-electroosmotic kusetshenziselwa ukugcina i-lens ingenamanzi, nakuba le ndlela idinga ukuthuthukiswa kwe-biocompatible enokwethenjelwa. amabhethri.
Ama-contact lens akhiqizwa ngokwesiko kusetshenziswa izindlela zokwenziwa kwe-lathe, ukwakha kanye ne-spin casting.Izinqubo zokubumba kanye ne-spin-casting zinezinzuzo ezingabizi kakhulu, kodwa ziphazanyiswa ukwelapha okuyinkimbinkimbi ngemva kokucubungula ukuze kuthuthukiswe ukunamathela kwempahla endaweni yokubunjwa. inqubo eyinkimbinkimbi futhi ebizayo enezingqinamba zokuklama.
Ukukhiqiza okungeziwe sekuvele njengenye indlela ethembisayo kumasu okukhiqiza amalensi okuxhumana avamile.Lawa masu ahlinzeka ngezinzuzo ezifana nokuncipha kwesikhathi, inkululeko enkulu yokuklama, kanye nokuphumelela kwezindleko.Ukuphrinta kwe-3D kwamalensi okuxhumana kanye nemishini yokubona kuseyinsakavukela, futhi ucwaningo lezi zinqubo azikho.Izinselele ziphakama ngokulahlekelwa izici zesakhiwo kanye nokunamathela okubuthakathaka okuhlangene kobuso ngemuva kokucubungula.Ukunciphisa usayizi wesinyathelo kubangela isakhiwo esibushelelezi, esithuthukisa ukunamathela.
Nakuba ucwaningo olwengeziwe lugxile ekusetshenzisweni kwezindlela zokunyathelisa ze-3D ukwenza ama-lens oxhumana nabo, kukhona ukuntuleka kwengxoxo mayelana nokwenza isikhunta uma kuqhathaniswa namalensi ngokwawo.Ukuhlanganisa ubuchwepheshe bokunyathelisa be-3D nezindlela zokukhiqiza zendabuko kunikeza okuhle kakhulu kokubili komhlaba.
Ababhali basebenzise indlela yenoveli ukuze baphrinte i-3D contact lens self-wetting.Isakhiwo esikhulu sakhiwe kusetshenziswa ukuphrinta kwe-3D, futhi imodeli yathuthukiswa kusetshenziswa i-AutoCAD kanye ne-stereolithography, indlela evamile yokuphrinta ye-3D. i-base arc ingu-8.5 mm. Usayizi wesinyathelo enqubweni yokukhiqiza ungu-10 µm kuphela, unqoba izinkinga zendabuko ngamalensi okuxhumana aphrintiwe e-3D.
Amalensi okuxhumana ahlakaniphile
Izindawo ezibonayo zamalensi okuxhumana akhiqiziwe zilungiswa kahle ngemva kokuphrinta futhi ziphindaphindwe ku-PDMS, into ethambile ye-elastomeric.Isu elisetshenziswe kulesi sinyathelo indlela ye-lithography ethambile.Isici esiyinhloko samalensi othintana naye aphrintiwe ukuba khona kwama-microchannels agobile ngaphakathi kwesakhiwo. , okubanikeza ikhono lokuzimanzisa.Ngaphezu kwalokho, ilensi inokudluliswa kokukhanya okuhle.
Ababhali bathola ukuthi isinqumo sesendlalelo sesakhiwo sichaza ubukhulu beziteshi ezincane, ezineziteshi ezinde eziphrintiwe phakathi kwelensi kanye nobude obufushane emaphethelweni ezakhiwo eziphrintiwe.Kodwa-ke, lapho zivezwa ku-oxygen plasma, izakhiwo zaba i-hydrophilic. , okwenza kube lula ukugeleza koketshezi oluqhutshwa yi-capillary nokumanzisa izakhiwo eziphrintiwe.
Ngenxa yokuntuleka kosayizi wesiteshi esincane nokulawula ukusatshalaliswa, amashaneli amancane anama-microchannel achazwe kahle kanye nemiphumela yesinyathelo encishisiwe aphrintwe esakhiweni esiyinhloko abese ephindaphindwa ku-lens yokuxhumana.Sebenzisa i-acetone ukuze upholishe izifunda ezibonakalayo zesakhiwo esikhulu futhi uphrinte ama-capillaries agobile. ukugwema ukulahleka kokudluliswa kokukhanya.
Ababhali bathi indlela yabo entsha ayithuthukisi nje kuphela ikhono lokuzithambisa lamalensi othintana naye aphrintiwe, kodwa futhi inikeza inkundla yokuthuthukiswa kwesikhathi esizayo kwamalensi okuxhumana anikwe amandla e-lab-on-a-chip.Lokhu kuvula umnyango wokusetshenziswa kwawo njengeqiniso elisebenzayo -izinhlelo zokusebenza zokuthola ama-biomarker wesikhathi.Sekukonke, lolu cwaningo lunikeza isiqondiso socwaningo esithakazelisayo sesikhathi esizayo samadivayisi we-biomedical asekelwe ku-lens yokuxhumana.
Isikhathi sokuthumela: Apr-30-2022
